‘Sure, that may be about correct. I seek for a physical knowledge of Organic systems within a base-up way. I do think you may distinguish 3 strains of study in my group in the mean time. The main issues chromosome construction: How will you receive a metre-extended DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation strategies that make it possible for us to check how, as an example, SMC proteins loop DNA (movie on Youtube) so as to build up chromosomes.
Our group studies bacterial mobile division and is also aiming to constitute a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major interest lies in mobile division, chromatin framework, and spatial Handle.
, Groningen researchers present the outcomes of their attempts to produce labs far more sustainable and supply tricks for other labs.
2007, to start with genuine-time detection of strand exchange in homologous recombination by RecA; discovery of the small persistence length of ends of microtubules; and fixed the system of biosensing with carbon nanotubes
We produce level-of-care diagnostics exam of neglected tropical conditions inside of resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in body fluids.
SMC complexes can go Actual physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic structures to pattern spatial boundaries for microbes and biomimetic vesicles with reconstituted protein networks which evaluate the basic part of spatial confinement on the molecular and cellular level. Our projects include the subsequent:
2000, discovery that nanotubes can carry incredible big latest densities; fixed the controversial concern of Digital transportation through DNA molecules by measurements of insulating conduct at The only molecule amount; and demonstration of an AFM approach for solitary-molecule manipulation of nanotubes
In 1993, for a youthful and eager associate professor at Delft College of Technological know-how, I had originally centered the investigate efforts of my group on measuring the electrical conductance of one conducting-polymer molecule. In just two many years, we had designed a tool wherein a single wire ceesdekker.net of a phthalocyaninepolysiloxane polymer was linked involving two intently spaced metallic nanoelectrodes.
But carbon nanotubes have remained a research subject matter of sizeable desire to quite a few. In fact, the outlook on employing carbon nanotubes to create useful gadgets, in regions including radio-frequency electronics, digital electronics and versatile electronics, stays vivid.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, very first demonstration of molecular sorting in a very lab with a chip utilizing biomotors; discovery of nanobubbles in reliable-point out nanopores; and to start with estimate of electrokinetic Power conversion in the nanofluidic channel
Developments in nanotechnology within the 1990s produced developing electronic gadgets from single molecules a chance. Cees Dekker recounts how his crew developed a area-temperature transistor determined by an individual carbon nanotube.
2013, controlled shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes